WCN26-9006 TARGETING FROUNT INHIBITS MACROPHAGE MIGRATION AND ACTIVATION SIGNAL, ATTENUATING GLOMERULAR INFLAMMATION AND TUBULOINTERSTITIAL FIBROSIS

Monocyte/macrophage (Mo/Mφ) accumulation exacerbates inflammation and fibrosis, contributing to renal injury in both glomerular and tubulointerstitial compartments. However, safe methods to control their deleterious actions without compromising host defense mechanisms remain to be established. FROUNT, an intracellular molecule highly expressed in Mo/Mφ, binds to the chemokine receptors CCR2 and CCR5 to amplify cell migration signaling. In this study, we investigated the therapeutic potential of targeting FROUNT in rodent models representing both glomerular and tubulointerstitial disease.