WCN26-4788 UNRAVELING A MYSTERIOUS COAGULOPATHY PRESENTING AS RENAL AND HEPATIC DYSFUNCTION

flow velocity (p < 0.001), wall shear velocity (p < 0.05), and vorticity (p < 0.05) (Fig. 2 (a,b)).In stratified analyses, patients with dyslipidemia show more pronounced characteristics.The results may indicate that differences in flow dynamics influence the interaction of blood molecules with ECs.By culturing iPSC-derived ECs on bio-printed hydrogel models based on CT analysis, we successfully constructed a bifurcation vascular model that preserved disease-specific shape (Fig. 2 (c)).ECs formed confluent luminal monolayers, and monocytes were perfused under defined flow.Monocyte adhesion was greater on the stenosismimicking branch than on the contralateral (healthy-mimicking) branch, consistent with an early atherogenic phenotype (Fig. 2 (d)).Conclusion: CFD analysis revealed hemodynamic drivers of unilateral RAS, and our system successfully recapitulated key pathophysiological features.This integrated approach enables mechanistic dissection of stenosis under patient-specific flow conditions and provides a novel platform for hypothesis testing and therapy/device development.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.