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Drug administration via the bloodstream involves some transport and reaction mechanisms ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m1"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi> <mml:mi>M</mml:mi> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> ), such as extravasation, perfusion along blood vessels, transmembrane and interstitial transport, protein dissociation and association, and lymphatic drainage. These <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m2"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi> <mml:mi>M</mml:mi> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> can be influenced by the type of pharmacokinetic ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m3"> <mml:mrow> <mml:mi>P</mml:mi> <mml:mi>K</mml:mi> </mml:mrow> </mml:math> ) profile used for drug delivery in the circulatory system, as well as by the bloodstream velocity <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m4"> <mml:mrow> <mml:mfenced open="(" close=")" separators="|"> <mml:mrow> <mml:msub> <mml:mi>λ</mml:mi> <mml:mrow> <mml:mi>i</mml:mi> <mml:mi>n</mml:mi> <mml:mi>l</mml:mi> </mml:mrow> </mml:msub> </mml:mrow> </mml:mfenced> </mml:mrow> </mml:math> . In electroporated tissues, the electric field magnitude ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m5"> <mml:mrow> <mml:mi>E</mml:mi> </mml:mrow> </mml:math> ) can also affect the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m6"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi> <mml:mi>M</mml:mi> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> because it brings about vessel vasoconstriction, cell membrane and vessel wall electro-permeabilization, and changes in tissue porosity. In the present work, in-house computational tools are employed to examine how the combination of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m7"> <mml:mrow> <mml:mi>E</mml:mi> </mml:mrow> </mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m8"> <mml:mrow> <mml:msub> <mml:mi>λ</mml:mi> <mml:mrow> <mml:mi>i</mml:mi> <mml:mi>n</mml:mi> <mml:mi>l</mml:mi> </mml:mrow> </mml:msub> </mml:mrow> </mml:math> influences the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m9"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi> <mml:msup> <mml:mi>M</mml:mi> <mml:mo>′</mml:mo> </mml:msup> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> existence, interaction, and rates arising in electrochemotherapy for two different <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m10"> <mml:mrow> <mml:mi>P</mml:mi> <mml:mi>K</mml:mi> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> : One-short tri-exponential ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m11"> <mml:mrow> <mml:mi>T</mml:mi> <mml:mi>P</mml:mi> <mml:mi>K</mml:mi> </mml:mrow> </mml:math> ), where the drug concentration decreases exponentially after a one-short infusion, and one uniform ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m12"> <mml:mrow> <mml:mi>U</mml:mi> <mml:mi>P</mml:mi> <mml:mi>K</mml:mi> </mml:mrow> </mml:math> ), where the drug concentration is kept constant during the whole treatment. First, the ratios between extracellular, free intracellular, and bound intracellular concentrations are obtained from numerical simulations with a meshless code previously developed, calibrated, and validated. Subsequently, the interaction between the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m13"> <mml:mrow> <mml:mi>R</mml:mi> <mml:mi>T</mml:mi> <mml:mi>M</mml:mi> <mml:mi>s</mml:mi> </mml:mrow> </mml:math> is investigated by means of a Boolean model presented here that is based on the comparison of the spatio-temporal evolution of the concentration ratios. Several combinations of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m14"> <mml:mrow> <mml:mi>E</mml:mi> </mml:mrow> </mml:math> ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m15"> <mml:mrow> <mml:mn>0</mml:mn> <mml:mtext> </mml:mtext> <mml:mi>k</mml:mi> <mml:mi>V</mml:mi> <mml:mo>/</mml:mo> <mml:mi>m</mml:mi> </mml:mrow> </mml:math> ; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m16"> <mml:mrow> <mml:mn>46</mml:mn> <mml:mtext> </mml:mtext> <mml:mi>k</mml:mi> <mml:mi>V</mml:mi> <mml:mo>/</mml:mo> <mml:mi>m</mml:mi> </mml:mrow> </mml:math> ; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="m17"> <mml:mrow> <mml:mn>70</mml:mn> <mml:mtext> </mml:mtext> <mml:mi>k</mml:mi> <mml:mi>V</mml:mi> <mml:mo>/</mml:mo> <mml:mi>m</mml:mi> </mml:mrow> </mml:math> ),