WCN26-1549 Myeloperoxidase-associated membranous nephropathy

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Authors

Kenta Tominaga · Self-Defense Forces Central Hospital

Namie Toyoda · Self-Defense Forces Central Hospital

Yuka Miyake · Self-Defense Forces Central Hospital

Aoi Yamashiro · Self-Defense Forces Central Hospital

Hanako Matsunobu · Self-Defense Forces Central Hospital

Tsugumi Fukunaga · National Defense Medical College Hospital

Hidehito Matsubara

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) (ANCA GN) is characterized as a pauci-immune type of crescentic GN. However, several studies have demonstrated the presence of membranous nephropathy (MN) as a rare concomitant pattern of ANCA GN. A granular pattern of myeloperoxidase (MPO) and immunoglobulin G (IgG) deposition along the glomerular basement membrane (GBM) was also observed in patients with MPO-ANCA GN and MN. Furthermore, MPO can be detected within subepithelial electron-dense deposits (EDD) in patients with MPO-ANCA GN accompanied by MN lesions.

Topics & Keywords

Vasculitis and related conditions Neutrophil, Myeloperoxidase and Oxidative Mechanisms Renal Diseases and Glomerulopathies

Publication Details

Published in: Kidney International Reports

Volume 11, Issue 4, pp. 106178-106178

DOI: 10.1016/j.ekir.2026.106178

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WCN26-1549 Myeloperoxidase-associated membranous nephropathy

Authors

Abstract

Topics & Keywords

Publication Details