WCN26-8227 DISCRIMINATIVE ABILITY OF A RISK SCORE IN PREDICTING THE DEVELOPMENT OF ACUTE KIDNEY INJURY IN THE EMERGENCY DEPARTMENT

Methods: This was a retrospective observational study done at our tertiary care centre to analyze the etiology, clinical manifestations, laboratory profile and outcomes in patients with biopsy-proven pigment-induced nephropathy between January 2017 and January 2024.History, clinical examination findings, laboratory investigations and outcomes were documented.Results: Our study population included 103 patients, out of which 60% were males.The mean follow-up was 12 2.5 months.Mean age was 41.8 14 years.88% (90) had oliguria and mean serum creatinine at presentation was 6.7 2.5 mg/dL.Rhabdomyolysis was noted in 68% (70) and hemolysis in 32% (33).Etiology of rhabdomyolysis include snake envenomation (11), seizures (7), trauma (24), sepsis (8), pancreatitis (6), drug induced (5), thyroid myopathy (2) and multiple substance abuse (7).Etiology of hemolysis include rifampicin induced (3), leptospirosis (5), mismatched blood transfusion reaction (3), snake bite (17), sepsis (3) and sickle cell disease (2).The mean duration of hospital stay was 10 2.36 days.73 patients (71 %) required hemodialysis (HD) during hospital stay and mean number of HD sessions was 10 5. Mortality was 18% (18).On statistical analysis, there was no significant difference between AKI due to rhabdomyolysis and hemolysis except for high creatine phosphokinase in patients with rhabdomyolysis and Lactate dehydrogenase level in patients with hemolysis.At follow-up, 9% (9) progressed to chronic kidney disease (CKD).Conclusion: Pigment nephropathy due to rhabdomyolysis and hemolysis is an important cause of dialysis requiring AKI .The prognosis was relatively good and depends on the etiology and complications I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.