Neutrophil Transcriptomic Changes in Severe Sterile Vasoplegic Syndrome Resemble a Distinct Molecular Subtype of Septic Shock

Dynamic gene expression in neutrophils from patients with severe vasoplegic syndrome includes both changes in response to surgery, and development of a gene expression phenotype resembling septic shock with elevated MMP8 expression. Our findings suggest a common neutrophil molecular program associated with multi-organ failure which may include common therapeutic targets for both sterile and septic systemic inflammatory states.