WCN26-3667 PATIENT EXPERIENCES WITH CANNABIDIOL FOR SYMPTOM MANAGEMENT IN KIDNEY FAILURE: QUALITATIVE INSIGHTS FROM THE SEISMIC-CBD TRIAL

Results:The cohort (N=150) had a mean age of 52.5 +/-12.8years, with 65.3% male and a high median dialysis vintage of 32 months (IQR: 18-60 months).We observed a marked disparity between physical and mental well-being: the mean PCS score (40.1 +/-11.5)was profoundly diminished compared to established general population norms, while the MCS score (51.2 +/-10.4) was relatively preserved, suggesting significant mental resilience in the face of physical decline.The most debilitating disease-specific domain scores were the Symptom/Problem List (45.2 +/-15.1)and the Burden of Kidney Disease (49.8 +/-14.5).Crucially, correlational analysis revealed a strong and statistically significant negative association between long-term dialysis vintage (>5 years) and PCS scores (r = -0.38,p<0.001), indicating a progressive erosion of physical function independent of initial diagnosis.Multiple regression models identified chronic anemia (Hb <10 g/dL) and comorbid DM (Type 2) as highly significant independent predictors of diminished scores across the Physical Functioning and Energy/Fatigue scales (p<0.01 for both).Conclusion: HRQoL is severely compromised in this South Indian dialysis cohort, with the primary morbidity concentrated in the physical, functional, and symptom-related domains.This study provides actionable data for resource allocation, demonstrating that while mental resilience is high, proactive intervention against long-term physical decay is essential.The clear negative impact of dialysis vintage, anemia, and diabetes mellitus necessitates a paradigm shift towards mandatory, structured, multidisciplinary interventions.We advocate for the routine integration of tailored physical rehabilitation programs and intensified clinical targets (Hb and glycemic control) alongside dialysis, establishing a cost effective,holistic care model applicable across similar ESKD centers in Asia to enhance both the duration and quality of life.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.