Transcriptomic Profiling of Relapsing-Remitting Multiple Sclerosis: Dysregulation of RNA Processing, Mitochondrial Metabolism, and Immune Pathways

This dataset contains transcriptomic profiles (raw and TPM-normalized counts) from 8 Relapsing-Remitting Multiple Sclerosis (RRMS) patients and 6 healthy controls. The study re-analyzes publicly available RNA-seq data from NCBI GEO accession GSE66573. Our analysis using DESeq2 identified 2,046 differentially expressed genes, revealing a convergent pattern of transcriptional dysregulation involving innate and adaptive immune activation, mitochondrial metabolic compensation, and RNA processing defects.