WCN26-1548 Predominant CD8+ cell infiltration and low accumulation of regulatory T cells in immune checkpoint inhibitor-induced tubulointerstitial nephritis

Conclusion:This case highlights a rare but increasingly recognized entity of drug-induced eosinophilic TIN with isolated ANA positivity, mimicking lupus serologically but lacking diagnostic criteria.The absence of specific autoantibodies and immune deposits, combined with toxic exposure history, supports a drug-induced mechanism.Recognizing this diagnostic pattern is crucial to differentiate druginduced injury from primary autoimmune disease and avoid misdiagnosis or overtreatment.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.