Methylphenidate Treatment and Risk of Psychotic Disorder

20260 citationsJournal Articlehybrid Open Access

Authors

Colm Healy · University College Dublin

Kirstie O’Hare · University of Edinburgh

Ulla Lång · University of Oulu

Johanna Metsälä · Oulu University Hospital

Anna Pulakka · University of Oulu

Jane McGrath · Trinity College Dublin

Maria Migone ·

Abstract

This study of national Finnish registry data for individuals with ADHD found no overall relationship between sustained treatment with methylphenidate risk of nonaffective psychosis; in secondary analyses, a potentially protective effect of methylphenidate treatment against later psychosis in children diagnosed with ADHD was found. Further research is needed to evaluate potential effects of treatment in individuals diagnosed in adolescence and adulthood.

Topics & Keywords

Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Research Neuroethics, Human Enhancement, Biomedical Innovations

Publication Details

Published in: JAMA Psychiatry

DOI: 10.1001/jamapsychiatry.2026.0152

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Methylphenidate Treatment and Risk of Psychotic Disorder

Authors

Abstract

Topics & Keywords

Publication Details