Filgotinib treatment modulates frequency and gene expression of circulating immune cell subsets in ulcerative colitis

20260 citationsJournal Article

Authors

Emily Wendt · Gilead Sciences (United States)

Yan Liang · Gilead Sciences (United States)

Grace Park · Gilead Sciences (United States)

Duncan Hindmarch · Washington Research Foundation

Ramya Kongala · Washington Research Foundation

Donna Shows · Washington Research Foundation

Angie Hertz

Abstract

Filgotinib response was associated with normalization of the cellular frequency and gene expression levels of B cells and phagocytic mononuclear cells in UC patients, resulting in immune profiles resembling those of healthy controls.

Topics & Keywords

Inflammatory Bowel Disease Spondyloarthritis Studies and Treatments Microscopic Colitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Crohn s and Colitis

Volume 20, Issue 3

DOI: 10.1093/ecco-jcc/jjag028

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