Degradable piezoelectric KNN/PLLA nanofibers for promoting osteogenesis and angiogenesis in bone regeneration

The 9 wt% KNN/PLLA nanofibers exhibited superior physicochemical and mechanical properties, a sevenfold increase in piezoelectric output. The nanofibers significantly enhanced bone regeneration, evidenced by upregulated osteogenic markers (OCN/RUNX2) and markedly improved ALP activity (60%) and ARS mineralization (70%). Coupled with favorable degradation and enhanced angiogenesis, the nanofibers demonstrate high potential for functional bone tissue engineering.