Alternating Hemispheric Diffusion-Weighted Imaging Abnormalities: A Characteristic Imaging Pattern in RHOBTB2 Encephalopathy

RADIOLOGICAL AWARENESSRHOBTB2-related developmental and epileptic encephalopathy, first molecularly characterized in 2018, is an emerging genetic disorder that poses unique diagnostic challenges for radiologists [1].De novo heterozygous missense variants in RHOBTB2, which encodes an atypical Rho GTPase involved in protein degradation pathways, produce a distinctive clinical-radiological phenotype.Recognition of this phenotype is gaining recognition as genetic testing expands into pediatric neurology practice [1,2].Affected children typically present with global developmental delay, infantile-onset epilepsy, movement