WCN26-2880 AVENANTHRAMIDE C FROM OATS EXERTS ANTI-INFLAMMATORY EFFECTS POSSIBLY VIA MODULATION OF ARYL HYDROCARBON RECEPTOR SIGNALING ON HUMAN UMBILICAL ENDOTHELIAL CELL

Chronic kidney disease (CKD) is closely linked to increased cardiovascular morbidity and mortality, with the uremic toxin indoxyl sulfate (IS) identified as a key contributor to disease progression. IS promotes vascular inflammation and accelerates atherosclerosis. In a previous study, we found that granola consumption may reduce serum IS levels in hemodialysis patients. Avenanthramide C (Ave), a polyphenol derived from oats, has antioxidant and anti-inflammatory properties; however, the precise mechanism underlying its anti-inflammatory effect remains unclear.