An ultra-sensitive cell-free DNA-based diagnostic assay for Tuberculous pleurisy utilizing the CRISPR-Cas13a system

20260 citationsJournal Articlegold Open Access

Authors

Weicong Ren · Beijing Chest Hospital

Mengjie Yang · Beijing Chest Hospital

You Zhou · The People's Hospital of Guangxi Zhuang Autonomous Region

Yinghui Yang · Jimei University

Haoran Li · Beijing Chest Hospital

Y. Chen · Beijing Chest Hospital

Shanshan Li ·

Abstract

The cfDNA-CRISPR assay based on the CRISPR-Cas13a system offers significantly improved sensitivity over conventional methods for detecting MTB in PE. It represents a promising, non-invasive diagnostic tool for enhancing TP detection in clinical practice.

Topics & Keywords

Pleural and Pulmonary Diseases Diagnosis and treatment of tuberculosis Tuberculosis Research and Epidemiology

Publication Details

Published in: Annals of Clinical Microbiology and Antimicrobials

DOI: 10.1186/s12941-026-00858-3

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An ultra-sensitive cell-free DNA-based diagnostic assay for Tuberculous pleurisy utilizing the CRISPR-Cas13a system

Authors

Abstract

Topics & Keywords

Publication Details