Ex Vivo Hypothermic Perfusion Enables 48‐Hour Heart Preservation and Bench‐Top Functional Recovery via Normothermic Reperfusion in a Porcine Model

HOPE enables 48 hours ex vivo heart preservation while maintaining cardiomyocyte integrity, normal gross and microscopic architecture, and rapid functional recovery on bench-top reperfusion in a preclinical model. These findings establish a foundation for redefining clinical preservation times and widening geographic donor access.