WCN26-6087 Vasopressin-dependent renal vasoconstriction and hypoxia after treadmill running in mice: A potential mechanism of exercise-induced acute kidney injury

Acute renal failure with severe loin pain and patchy renal ischemia after high-intensity exercise (ALPE) is a unique form of acute kidney injury. Although heterogeneous renal vasoconstriction has been implicated, its molecular mechanism remains unclear. Arginine Vasopressin (AVP) have a potent vasoconstrictor acting through the AVP receptor 1A (AVPR1A). This study aimed to clarify whether exercise augments AVP-induced renal vasoconstriction and hypoxia via AVPR1A signaling.