Lp(a) Has Specific Effects on Coronary Artery Disease Independent of LDL-C

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Authors

Moa P. Lee · University of North Carolina at Chapel Hill

Sarah H. Koenigsberg · University of North Carolina at Chapel Hill

Mohammad Yaser Anwar · University of North Carolina at Chapel Hill

Laura M. Raffield · University of North Carolina at Chapel Hill

Zhaotong Lin · Florida State University

Anna F Ballou · University of North Carolina at Chapel Hill

John N. Booth

Abstract

Increasing Lp(a) exposure had direct, independent causal effects on coronary artery disease and HbA1c only; very low Lp(a) exposure is suggested to not be causally associated with type 2 diabetes. The optimal European and African ancestry threshold to stratify cardiovascular risk is comparable, and below 125/105 nmol/L in current U.S./European medical professional society guidelines.

Topics & Keywords

Lipoproteins and Cardiovascular Health Atherosclerosis and Cardiovascular Diseases Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JACC Advances

Volume 5, Issue 5, pp. 102697-102697

DOI: 10.1016/j.jacadv.2026.102697

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