<i>In vitro</i> study of spatially-fractionated radiotherapy (SFRT) with gold nanoparticles in cancerous and healthy skin cells

This study revealed a differential cell type response in monoculture versus co-culture following AuNPs and irradiation. Both monocultures exhibited up to 1.6-fold increase in DNA damage following combined therapy compared to radiation only. In co-culture, combined treatment increased DNA damage relatively more in melanoma. These findings show promise in selectively enhancing DNA damage in melanoma.