Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes

20260 citationsJournal Articlehybrid Open Access

Authors

Guk Jin Lee · The Catholic University of Korea Bucheon St. Mary's Hospital

Sang‐Hyuk Jung · Kangwon National University

Jonghyun Lee · University of Pennsylvania

Ki Won Moon · Kangwon National University

Penn Medicine Biobank · Translational Therapeutics (United States)

Jae‐Seung Yun · The Catholic University of Korea St. Vincent's Hospital

Dokyoon Kim

Abstract

PrCa PRS effectively stratifies risk among men with and without T2DM, highlighting the independent contribution of genetic susceptibility. Lower IGF-1 levels in T2DM patients may partly mediate the reduced PrCa risk, suggesting a possible biological mechanism underlying these observations.

Topics & Keywords

Growth Hormone and Insulin-like Growth Factors Pituitary Gland Disorders and Treatments Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes Obesity and Metabolism

DOI: 10.1111/dom.70690

Field-Weighted Citation Impact: 0.00