Bidirectional Roles of <scp>TRPV1</scp> in a Latent Sensitization Model of Myofascial Low Back Pain

20260 citationsJournal Articlehybrid Open Access

Authors

Vivian Blechschmidt · University of Mannheim

Bastian Schlickenrieder · University of Mannheim

Jonathan R. Husk · University of Mannheim

Ulrich Hoheisel · University of Mannheim

Handan Mörz · University of Mannheim

Rolf‐Detlef Treede · University of Mannheim

Wolfgang Greffrath ·

Abstract

TRPV1 contributes to NGF-induced sensitization but is not required for its development. These findings put TRPV1's potential as a therapeutic target for hyperalgesia into perspective and suggest a potential regulatory role in pain homeostasis.

Topics & Keywords

Pain Mechanisms and Treatments Ion Channels and Receptors Gastrointestinal motility and disorders

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: European Journal of Pain

Volume 30, Issue 4, pp. e70255-e70255

DOI: 10.1002/ejp.70255

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