Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway

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Authors

Zhe Jiang · Central South University

Xueliang Chen · Chenzhou First People's Hospital

Qi Sun · Central South University

Li-chao Yang · Central South University

Ya-wei Zhang · Central South University

Qiang Wu · Central South University

Hengchang Yao ·

Abstract

This study is the first to comprehensively demonstrate that matrine directly targets the JAK2/STAT3 signaling axis to restore bile acid homeostasis and suppress inflammation in experimental colitis with validation in human UC patients, providing novel mechanistic and translational insight into how matrine may benefit colitis.

Topics & Keywords

Drug Transport and Resistance Mechanisms Berberine and alkaloids research Inflammatory Bowel Disease

Publication Details

Published in: Chinese Medicine

Volume 21, Issue 1

DOI: 10.1186/s13020-026-01387-z

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Matrine improves bile acid metabolism and reduces inflammatory and oxidative stress in colitis via the JAK2 pathway

Authors

Abstract

Topics & Keywords

Publication Details