Identification a rare chromosomal translocation 45,X, der(Y;15)(q11.2;q11.2) in an azoospermic patient using C-MoKa

In this study, the C-MoKa technique was used to identify a rare case of Y chromosome translocation involving chromosome 15 in a male with Turner syndrome, which was challenging to detect using conventional chromosomal G-banding and CNV-seq. C-MoKa is a rapid and accurate cytogenetic detection method that offers high-resolution detection of structural variations and improved breakpoint characterization, thereby overcoming the limitations of traditional karyotyping approaches.