Salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance: A longitudinal study

The study demonstrated a significant increase in salivary IGF-1 levels within 7-10 days, with BALP levels peaking at 6-10 weeks. These findings suggest a potential role of IGF-1 and BALP in the biochemical response to Twin Block appliance therapy.