Reversible electroporation triggers the release of microvesicles affecting viability, migration, and adhesion of melanoma cells

Reversible electroporation alters not only MV secretion but also their biological activity, inducing MV-mediated bystander effects that suppress key pro-metastatic properties of melanoma cells. These findings suggest that electroporation may modulate the tumor microenvironment beyond membrane permeabilization, supporting its safety and therapeutic potential while highlighting cell type-specific effects that warrant further investigation.