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<h3>Introduction</h3> Oral Candidiasis (OC) is prevalent in hospice inpatients with life-limiting illnesses and associated immunocompromise, often resulting in severe and persistent infections with high symptom burdens. 37.1% of St John’s Hospice inpatients received OC treatment (December 2024-July 2025), with frequent prolonged/multiple treatment courses and infection relapse/recurrence. Updated national guidance (NICE CKS, 2025) endorses intensive treatment with Fluconazole loading and higher dosing but acknowledges numerous cautions and drug-interactions. Best practice oral hygiene is key to OC eradication, as per the national Mouth Care Matters guide (Doshi, 2019). <h3>Methods</h3> The project aimed to achieve: 1) 90% concordance with NICE guidelines for Nystatin and Fluconazole prescribing; 2) 75% concordance with best practice for patient advice on mouthcare and applying Nystatin; 3) significant increase in treatment success rates, reduced infection relapse/recurrence and prolonged/multiple treatment courses. Multidisciplinary team (MDT) discussions shaped interventions: i) treatment summary guide and poster; ii) MDT teaching; iii) mouthcare packs and patient information leaflets on mouthcare and applying Nystatin. Concordance with NICE prescribing standards for Nystatin and Fluconazole was measured and plotted alongside treatment outcome data on run-charts. Pre- and post-intervention staff questionnaires on patient advice were scored against best practice and analysed using T-tests. <h3>Results</h3> Post-intervention, Nystatin and Fluconazole prescribing run-charts showed significant positive shifts and median scores reached 0.75 and 1.00 respectively. No adverse drug events occurred post-intervention. Staff questionnaire performance significantly improved to 61.4% and 84.1% for patient advice on mouthcare and applying Nystatin respectively (p<0.005). Run-chart data for patients receiving multiple treatment courses showed significant downward shift to 21.5%. Non-significant higher treatment success rates, reduced infection relapse/recurrence and fewer prolonged treatment courses were observed. <h3>Conclusions</h3> Post-intervention, practice improved meeting targets for Fluconazole prescribing, advice on applying Nystatin, and fewer patients required multiple treatment courses. Further teaching and embedding leaflets into practice is planned to meet outstanding aims. <h3>References</h3> Doshi, M. (2019). Mouth Care Matters a Guide for Hospital Healthcare Professionals, 2nd Edition, Version 13. Surrey & Sussex NHS Trust: Health Education England, pp.21–48. [online] Available at: https://mouthcarematters.hee.nhs.uk/wp-content/uploads/sites/6/2020/01/MCM-GUIDE-2019-Final.pdf [Accessed 21 May 2025]. NICE Clinical Knowledge Summary (2025). Candida Oral - Management - Scenario: Adults and young people. NICE, Clarity Informatics Ltd. [online] Available at: https://cks.nice.org.uk/topics/candida-oral/management/adults-young-people-not-immunocompromised [Accessed 21 May 2025].