Effects of dentin extract without demineralization on migration and angiogenic potential of human umbilical vein endothelial cells

In conclusion, this study demonstrates that DE, without demineralization, promotes cell proliferation, migration, and angiogenesis in HUVECs via the Notch and VEGF/VEGFR2 signaling pathways. These findings suggest that dentin, without the need for demineralization, could serve as a viable alternative to conventional bone graft materials, offering a more streamlined process for regenerative surgery.