Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids

Local therapy offers a valuable and often well-tolerated first step in managing ND. Unfortunately, high-quality evidence is scarce and treatment efficacy remains unpredictable. Clinicians are advised to start with low concentrations, discuss off-label use, and monitor for side effects. Until robust guidelines are available, a cautious trial-and-error approach remains the cornerstone of management.