Clinical characteristics and mortality risk factors among 400,509 individuals diagnosed with AIDS in Brazil: A nationwide observational study

Mortality was driven by AIDS-defining conditions, particularly non-Hodgkin lymphoma, extrapulmonary cryptococcosis, and disseminated histoplasmosis. Classic signs and symptoms (prolonged fever, weight loss, cytopenias) also predicted death. Early recognition and timely treatment of these high-risk presentations are essential in Brazil.