Characterisation of the signal to noise ratio of 2-photon microscopes

20260 citationsJournal Articlegold Open Access

Authors

Radek Macháň · Nanyang Technological University

Shau Poh Chong · Nanyang Technological University

Khee Leong Lee · Nanyang Technological University

Peter Török · Nanyang Technological University

Abstract

The signal to noise ratio (SNR) is a key performance metric of an imaging instrument. Here we describe the characterisation of SNR of a custom 2-photon microscope and compare the SNR performance of our microscope with selected commercial 2-photon microscopes. The methodology described in this paper can serve as guidance for others wishing to characterise and benchmark their 2-photon or other point-scanning microscopes.

Topics & Keywords

Advanced Fluorescence Microscopy Techniques Integrated Circuits and Semiconductor Failure Analysis Advanced Optical Sensing Technologies

Publication Details

Published in: Scientific Reports

DOI: 10.1038/s41598-026-45224-7

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Characterisation of the signal to noise ratio of 2-photon microscopes

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Abstract

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Publication Details