Angiotensin‐(1–7) Alleviates Isoproterenol‐Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin <scp>II</scp> Type 2 Receptor

20260 citationsJournal Articlehybrid Open Access

Authors

Xin Wang · Yanbian University

Fei Guo · Yanbian University

Xin Wang · Yanbian University

Yu Guo · Yanbian University

Siyao Fan · Yanbian University

Lan Hong · Yanbian University

Honghua Jin · Yanbian University

Abstract

Ang-(1-7) ameliorates ISO-induced cardiac hypertrophy by suppressing excessive autophagy and apoptosis via synergistic MasR-AT<sub>2</sub>R signaling. Receptor crosstalk may represent a therapeutic entry point for pathological hypertrophy.

Topics & Keywords

Renin-Angiotensin System Studies Autophagy in Disease and Therapy Cardiac Fibrosis and Remodeling

Publication Details

Published in: Acta Physiologica

Volume 242, Issue 4, pp. e70200-e70200

DOI: 10.1111/apha.70200

Field-Weighted Citation Impact: 0.00

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Angiotensin‐(1–7) Alleviates Isoproterenol‐Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin <scp>II</scp> Type 2 Receptor

Authors

Abstract

Topics & Keywords

Publication Details