Search for a command to run...
<b>Objective:</b> To analyze the epidemic trend and spatiotemporal distribution characteristics of human brucellosis (brucellosis) in 16 cities (autonomous prefectures) of Yunnan Province from 2006 to 2024, and to provide a reference basis for the prevention and control of brucellosis in Yunnan Province. <b>Methods:</b> The data were derived from the Infectious Disease Surveillance Information System of the Chinese Disease Prevention and Control Information System, collecting the reported cases of brucellosis in 16 cities (autonomous prefectures) of Yunnan Province from 2006 to 2024. Data were collated in Excel 2021, and data visualization was conducted using R 4.5.0 and Origin 2024 software. The annual percent change and average annual percent change (AAPC) of brucellosis incidence were calculated using Joinpoint 5.4.0 software for time-trend analysis. Spatial autocorrelation analysis was conducted using ArcGIS 10.8 software, and spatiotemporal scanning analysis was carried out using SaTScan 10.3.2 software. <b>Results:</b> From 2006 to 2024, a total of 7 350 cases of brucellosis were reported in Yunnan Province, and the reported incidence rate increased from 0.002 per 100 000 to 4.563 per 100 000. The Joinpoint regression analysis results showed that the upward trend of reported incidence rates from 2006 to 2024 was statistically significant (AAPC=49.01%, <i>P</i><0.001). The global Moran's <i>I</i> value ranged from 0.25 to 0.40. The years with statistical significance were 2008, 2011, 2017-2018, and 2021-2024, respectively. There was significant positive spatial autocorrelation (all <i>P</i><0.05), indicating spatial aggregation in the reported incidence of brucellosis. The global <i>G</i> coefficient ranges from 0.15 to 0.22. The years with statistical significance are 2008-2009, 2011, and 2017-2024, respectively, indicating that the reported incidence rate shows a high degree of spatial aggregation. The Moran's <i>I</i> value and the <i>G</i> coefficient from 2021 to 2024 were both >0.00. It indicates that the reported incidence rate showed a high level of aggregated positive spatial autocorrelation. The results of local autocorrelation analysis show that the high-high aggregation areas have gradually shrunk from cities (autonomous prefectures) including Kunming, Honghe, Qujing, and Yuxi in 2017 to Kunming, Qujing, and Zhaotong from 2022 to 2024. The hotspots were concentrated from six cities (autonomous prefectures) in 2008 to 2020 to two cities (Kunming and Qujing) in 2021 to 2024. The results of spatio-temporal scanning analysis showed that the five spatio-temporal clustering areas were statistically significant (all <i>P</i><0.05), and covered nine cities (autonomous prefectures). The first-class clustering areas were Zhaotong, Qujing and Kunming in the northeastern part of Yunnan Province. <b>Conclusions:</b> From 2006 to 2024, the brucellosis epidemic in Yunnan Province showed a continuous upward trend. The hotspots and spatiotemporal concentration areas are mainly distributed in the northeastern part of Yunnan Province. Kunming and Qujing are the key areas for brucellosis prevention and control. The increase in cities (autonomous prefectures) including Zhaotong, Baoshan and Wenshan is relatively large and should also be closely monitored. Precise measures should be adopted to control the brucellosis epidemic.