Clinical Utility of Pentraxin-3 and Eosinophil-Derived Neurotoxin as Biomarkers of Disease Activity in Pediatric Bronchial Asthma

EDN and PTX3 are associated with pediatric asthma, reflecting different components of airway inflammation. EDN demonstrated closer relationships with markers of disease activity suggesting its potential role as an adjunct biomarker for monitoring inflammation, while PTX3 primarily differentiated asthmatic from healthy children. These biomarkers should be considered complementary research tools rather than stand-alone diagnostic tests.