Presence of koilocytes in actinic keratosis identifies those at high risk of developing keratinocyte carcinoma

20260 citationsJournal Article

Authors

Huw Morgan · Cardiff University

Richa A Deorukhkar · Cardiff University

William Tuckwell · Cardiff University

Boris Shorning · Cardiff University

Nitya Malladi · University Hospital of Wales

W John Watkins · Institute of Infection and Immunity

Majid Rashid ·

Abstract

The presence of koilocytes in AK histology is indicative of a subset of patients at risk of multiple KCs. Inhibiting Src kinase blocked this HPV8-associated keratinocyte proliferation and prevented skin tumours in a mouse model.

Topics & Keywords

Nonmelanoma Skin Cancer Studies Head and Neck Cancer Studies Cutaneous Melanoma Detection and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Dermatology

DOI: 10.1093/bjd/ljag016

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