Exploring anticancer leads from bioactive compounds of Rutaceae family

In recent years, phytochemicals have attracted attention for their possible role in cancer treatment. Studies have shown that they can slow down the growth of cancer cells, trigger cell death and help control harmful processes in the body. However, most of this research is still at an early stage, mainly based on laboratory studies and more work is needed to confirm their safety and effectiveness in humans. But through traditional systems, medicinal plants continues to stay integrated with the well being of our lives and the family Rutaceae holds a special place among them. This family includes well-known plants such as Aegle marmelos, Citrus species, Murraya koenigii, Ruta and Zanthoxylum, many of which are commonly used in everyday remedies. These plants are rich in natural compounds like alkaloids, coumarins, flavonoids and essential oils, which are known for various health benefits. At the same time, with cancer cases increasing worldwide, there is a growing need to explore safer and more affordable treatment options. In this context, Rutaceae plants offer promising possibilities. This review focuses on their traditional uses, important chemical compounds and their potential role in cancer research, while also highlighting the need for further detailed studies.