Search for a command to run...
C-reactive protein structurally belongs to the pentraxin family, calcium-binding proteins with immune defense properties. In the serum of healthy adults and adolescents, there is less than 5 mg of C-reactive protein. Its concentration is increased in inflammatory diseases where values up to 500 mg/l can be found. The main role of C-reactive protein is complement activation and prevention of inflammation. It binds to bacteria or damaged cells and thus helps the activation of the classic complement pathway, opsonization and phagocytosis. Binding depends on calcium. Antibiotics are products of the metabolism of bacteria, fungi and molds, rarely higher plants, which in small concentrations prevent the growth and development of microorganisms or kill them. They belong to the group of antimicrobial drugs, which are used to treat and prevent bacterial infections. Cephalosporins are beta-lactam antibiotics with the same mechanism of action as penicillin, which means that they block the synthesis of the bacterial cell wall. Cefazolin is a beta-lactam antibiotic, which belongs to the first generation cephalosporins. It is administered parenterally and acts on gram positive bacteria. Ceftriaxone is a beta-lactam antibiotic, which belongs to the third generation cephalosporins. It is administered parenterally with a very long elimination half-life, so once-daily dosing is sufficient for most indications. It is highly effective against Enterobacter, Citrobacter, Proteus and Pseudomonas species. The aim of the work is to determine whether the value of C-reactive protein, in the serum of postoperative patients, is lower after the administration of the antibiotic ceftriaxone, compared to cefazolin. From the study, it can be concluded that antibiotic therapy, in postoperative patients, affects the reduction of the value of C-reactive protein as a marker of inflammation, which further affects the reduction of inflammation in the same patients. Likewise, it was determined that the antibiotic ceftriaxone has a better effect on lowering the value of C-reactive protein, in postoperative patients, compared to the antibiotic cefazolin. Key words: C-reactive protein, cefazolin, ceftriaxone