Metabolic engineering of Streptomyces albulus for de novo serotonin production

20260 citationsJournal Articlegold Open Access

Authors

Yuan Zhang · Binzhou Medical University

Ao Liu · Binzhou Medical University

M D Zhang · Binzhou Medical University

Jiabei Song · Binzhou Medical University

Qian Wang · Binzhou Medical University

Yongxuan Liu · Binzhou Medical University

Qingshou Yao ·

Abstract

This work establishes S. albulus as an efficient microbial platform for high-level 5-HT production. The engineered strain and optimized fermentation process demonstrate strong potential for industrial application and provide a versatile chassis for synthesizing diverse tryptophan-derived bioactive compounds.

Topics & Keywords

Biochemical and biochemical processes Microbial Metabolic Engineering and Bioproduction Microbial Natural Products and Biosynthesis

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Microbial Cell Factories

DOI: 10.1186/s12934-026-02995-y

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