Genetic variations associated with immediate hypersensitivity reactions to iodinated contrast media: A whole exome sequencing study

FASTKD1 and HACL1, which are involved in mitochondrial and metabolic regulation, and SIRPB1, which participates in innate immune signaling, were identified as candidate genes potentially associated with ICM-induced immediate HSRs. These suggest a possible contribution of both metabolic and immune regulatory pathways to genetic susceptibility and require validation in larger, independent cohorts before clinical application.