Initial Disease Severity and Methimazole Titration for Graves’ Disease: A Retrospective Longitudinal Cohort Study

When given a larger dose of methimazole, patients with severe thyrotoxicosis from GD reach euthyroid status as quickly as other patients with GD. However, these patients have more lability in thyroid control and may benefit from more frequent monitoring. After 6 months, severity of initial thyrotoxicosis was not associated with methimazole dose.