Potential Of Self Microemulsifying Drug Delivery System: An Overview

Self-microemulsifying drug delivery systems (SMEDDS) are a promising method for improving the bioavailability of water-soluble drugs. These systems form fine oil-in-water micro emulsions in the gastrointestinal tract, eliminating high-energy input and ensuring uniform formulations. However, they face challenges such as component selection and potential side effects. SMEDDS are used in the pharmaceutical industry for class II and IV drugs and are advancing with emerging technologies and multidisciplinary collaborations. Keywords: Self-Microemulsifying Drug Delivery Systems (SMEDDS), Poorly Water-Soluble Drugs, Oral Drug Delivery, Oil-in-Water Microemulsions, Surfactants and Co-surfactants.