Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study

20260 citationsJournal Article

Authors

Sergio M. Navarro · University of Minnesota

Riley J. Thompson · Mayo Clinic

Grant M. Spears · Mayo Clinic

Kent R. Bailey · Mayo Clinic

Theresa K. Kelly · Henderson Community College

Christina Wheeler · Henderson Community College

Jing-Fei Dong ·

Abstract

Levels of the H3.1 and H3R8 Cit nucleosomes are elevated early after traumatic injury, especially in those who developed VTE. These findings underscore the importance of understanding the pathophysiology of nucleosomes in inducing VTE and their role as biomarkers.Study Type: Prospective study with less than large effect and no negative criteria.Level of Evidence: II.

Topics & Keywords

Acute Myeloid Leukemia Research Venous Thromboembolism Diagnosis and Management Blood Coagulation and Thrombosis Mechanisms

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Shock

DOI: 10.1097/shk.0000000000002807

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