IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8 <sup>+</sup> T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

20260 citationsJournal Articlehybrid Open Access

Authors

Fengtian Wu · National Centre for Infectious Diseases

Zixuan Guo · National Centre for Infectious Diseases

Jun Guan · National Centre for Infectious Diseases

Jia Xu · National Centre for Infectious Diseases

Yao Chen · National Centre for Infectious Diseases

Zhi Chen · National Centre for Infectious Diseases

Abstract

Combined IL-15 and Tα1 therapy reverses CD8<sup>+</sup> T cell senescence and enhances antitumor immunity in HCC through suppression of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.

Topics & Keywords

T-cell and B-cell Immunology Cancer Immunotherapy and Biomarkers interferon and immune responses

Publication Details

Published in: Journal of Gastroenterology and Hepatology

DOI: 10.1111/jgh.70359

Field-Weighted Citation Impact: 0.00

Command Palette

IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8 <sup>+</sup> T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Authors

Abstract

Topics & Keywords

Publication Details