Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

SM-23 enhances MEK/ERK pathway inhibition through improved kinase binding affinity and demonstrates potent antiproliferative activity in colorectal cancer cells. These findings identify SM-23 as a promising MEK/ERK-targeted candidate for further therapeutic development.