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For almost 50 years, field-effect principle-based sensors have been employed in a wide range of applications, such as radiation detection, environmental parameter monitoring, and biochemical sensing. For sensing applications, field effect transistors (FET) are a well-established technology. As one of the most significant electronic components, high-performance FETs have advanced significantly over the last few decades. More significantly, each component of a FET may use a separate sensing method to sense external mechanics because to the device's distinctive three-terminal configuration. Wearable biosensors’ quick development has completely changed healthcare monitoring by enabling continuous, non-invasive screening. This paper examines the cutting-edge advancements and uses of wearable biosensors based on FET technology for medical monitoring. This work seeks to provide a multifaceted view on device design, manufacturing, functionalization, and applications, making it a useful tool for biomedical and healthcare researchers.