BIT1 as an Effector of EGFR-TKI-induced Apoptosis <i>via</i> TLE1 Inhibition in Lung Adenocarcinoma Cells

The Bit1/TLE1 axis is a pivotal regulatory switch dictating apoptotic outcomes following EGFR-TKI treatment. This mechanism identifies a therapeutic vulnerability, suggesting that pharmacological Bit1 pathway activation could be an effective strategy to overcome acquired resistance in LUAD.