Does Curative Radiotherapy Impact Fatigue Onset in Prostate Cancer Patients? An Analysis of 1253 Patients

In this extensive cohort of PC patients, approximately 30% experienced moderate to severe fatigue before initiating RT, with less than 20% reporting new or exacerbated fatigue post-treatment. Factors including treatment-related toxicities, hypofractionation, alcohol use, and ADT were significant contributors to fatigue. These findings underscore the complexity of managing fatigue in PC, highlighting the influence of both treatment modalities and lifestyle factors.