High-dose Olanzapine Versus Clozapine in Treatment-resistant Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

While this meta-analysis revealed no significant difference in efficacy between clozapine and HDO for most outcomes, HDO did show a significant efficacy advantage over clozapine in the treatment of negative symptoms in adults with TRS. Adverse events were more frequently reported in the clozapine group, suggesting a more favorable safety profile for HDO. These results support HDO as a viable and potentially safer alternative to clozapine in the management of TRS.