Sexual Dimorphism and Age Effects in CKD and Type 2 Diabetes in the CONFIDENCE Trial

20260 citationsJournal Articlehybrid Open Access

Authors

Rajiv Agarwal · Richard L. Roudebush VA Medical Center

Jennifer B Green · Duke University

Hiddo J L Heerspink · University Medical Center Groningen

Johannes F E Mann · Friedrich-Alexander-Universität Erlangen-Nürnberg

Janet B. McGill · Washington University in St. Louis

Amy K. Mottl · University of North Carolina at Chapel Hill

Masaomi Nangaku

Abstract

The UACR-lowering response of finerenone and empagliflozin scaled linearly with age (10% per decade) and sex (~20% more among women). The benefit of combination therapy was independent of age and sex.

Topics & Keywords

Diabetes Treatment and Management Chronic Kidney Disease and Diabetes Pancreatic function and diabetes

UN Sustainable Development Goals

Gender equality

Publication Details

Published in: Nephrology Dialysis Transplantation

DOI: 10.1093/ndt/gfag075

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