<scp>Metallothionein</scp> Safeguards Hepatic Zn‐Fe Homeostasis and Restrains Yap‐Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis

20260 citationsJournal Article

Authors

Yinrui Feng · Sichuan University

Zixuan Zhou · Sichuan University

Ying Xiao · Sichuan University

Yundi Liu · Sichuan University

Yide Ma · Lanzhou University Second Hospital

Dan Wang · Sichuan University

Tao Wang · Sichuan University

Abstract

These findings reveal MT as a key hepatocyte integrator of trace-metal homeostasis and Yap signalling and suggest that therapeutic strategies enhancing MT activity or combining Zn supplementation with Yap inhibition may offer new avenues to prevent or reverse chronic liver fibrosis.

Topics & Keywords

Trace Elements in Health Liver physiology and pathology Ferroptosis and cancer prognosis

Publication Details

Published in: Liver International

Volume 46, Issue 5, pp. e70624-e70624

DOI: 10.1111/liv.70624

Field-Weighted Citation Impact: 0.00

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<scp>Metallothionein</scp> Safeguards Hepatic Zn‐Fe Homeostasis and Restrains Yap‐Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis

Authors

Abstract

Topics & Keywords

Publication Details