Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

20260 citationsJournal Articlehybrid Open Access

Authors

Stellene Vitaro · Flinders University

Geraldine Laven-Law · Flinders University

Ganessan Kichenadasse · Flinders University

Kathryn Cornthwaite · Flinders University

Erin L Symonds · Flinders University

Jean M Winter · Flinders University

Abstract

Bisulfite conversion has higher DNA methylation levels for certain CRC biomarkers in tumor tissues, suggesting over-estimation of methylation that could affect biomarker specificity.

Topics & Keywords

Epigenetics and DNA Methylation RNA modifications and cancer Ferroptosis and cancer prognosis

Publication Details

Published in: Clinical Chemistry

DOI: 10.1093/clinchem/hvag018

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Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

Authors

Abstract

Topics & Keywords

Publication Details